Fri Jan 06 2023

31 articles - From Friday Dec 30 2022 to Friday Jan 06 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults: A Living Clinical Guideline From the American College of Physicians.

The patient population includes adults with primary osteoporosis or low bone mass. Recommendation 1a

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Meta-analysis

meta-analyses and systematic reviews

Ann Intern Med

Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis : A Living Systematic Review and Network Meta-analysis for the American College of Physicians.

Bisphosphonates, denosumab, abaloparatide, teriparatide, and romosozumab, followed by alendronate, reduce clinical fractures in postmenopausal females with osteoporosis. Abaloparatide and teriparatide increased WAEs; longer duration bisphosphonate use may increase AFF and ONJ risk though these events were rare. Primary funding source American College of Physicians. (PROSPERO CRD42021236220).

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

In cancer with dyspnea, high-dose dexamethasone did not improve dyspnea and increased SAEs.

2022; 23:1321-31. 36087590.

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In glucocorticoid-dependent polymyalgia rheumatica, tocilizumab improved a composite clinical outcome at 24 wk.

2022; 328:1053-62. 36125471.

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In older adults with recent MI, polypill vs. usual care reduced major adverse CV events at 3 y.

2022; 387:967-77. 36018037.

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In rheumatic heart disease-associated AF, rivaroxaban increased adverse vascular outcomes vs. VKA at 3 y.

2022; 387:978-88. 36036525.

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In T1DM, open-source automated insulin delivery increased glucose time in target vs. sensor-augmented pumps.

2022; 387:869-81. 36069869.

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In tobacco smokers with respiratory symptoms, a dual bronchodilator did not reduce symptoms at 12 wk.

2022; 387:1173-84. 36066078.

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In type 2 diabetes, glargine and liraglutide each improved glycemic outcomes at 5 y vs. glimepiride or sitagliptin.

2022; 387:1063-74. 36129996.

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In type 2 diabetes, liraglutide reduced CV events at 5 y vs. glargine, glimepiride, or sitagliptin.

2022; 387:1075-88. 36129997.

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In type 2 diabetes, the BT-001 smartphone app reduced HbA1c more than a control app at 90 d.

2022; 45:2976-81. 36181554.

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Short-Term Adverse Outcomes After Mifepristone-Misoprostol Versus Procedural Induced Abortion : A Population-Based Propensity-Weighted Study.

Although rare, short-term adverse events are more likely after mifepristone-misoprostol IA than procedural IA, especially for less serious adverse outcomes. Primary funding source Canadian Institutes of Health Research.

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Statins increase muscle pain or weakness at 1 y, with an absolute excess of 11 events/1000 person-y.

2022; 400:832-45. 36049498.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

N Engl J Med

Audio Interview: The Expanding Arsenal of Oral Agents to Treat Covid-19.

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More COACHing Needed to Optimize Care after Heart Failure Hospitalization.

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Moving the Needle on Alzheimer's Disease with an Anti-Oligomer Antibody.

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New Approaches to Chronic Hepatitis B.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Annals On Call - Atrial Fibrillation: Control Rate or Rhythm?

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Annals Video Summary - Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis.

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Osteoporosis Treatment: Not Easy.

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Summary for Patients: Pharmacologic Treatment of Primary Osteoporosis or Low Bone Mass to Prevent Fractures in Adults.

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Summary for Patients: Short-Term Adverse Outcomes After Mifepristone-Misoprostol Versus Procedural Induced Abortion.

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The War on Reproductive Health Care in the United States.

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N Engl J Med

A Stormy Heart.

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Death by Ableism.

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Evidence over Politics - The U.S. Preventive Services Task Force.

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Locomotor Brachii Sign in Aortic Regurgitation.

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Letters&Replies

Letters to the editors and authors’ replies

N Engl J Med

Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke.

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Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke.

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Trial of Intravenous Immune Globulin in Dermatomyositis.

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Trial of Intravenous Immune Globulin in Dermatomyositis. Reply.

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